ABSTRACT
Objective@#Under the intervention of modern holistic medical model, the subjective feelings and objective effects of parents and children in circumcision were studied in children aged 3-6 years.@*Methods@#A prospective study was conducted to select 2012 children aged 3 to 6 years who underwent circumcision at the First Affiliated Hospital of Kunming Medical University from August 2013 to May 2017. The patients were divided into control group and experimental group by completely randomized grouping, there were 1 006 cases in each group. The children in the control group were treated with a single biomedical model, which was completed according to the conventional flow-type operation. The children in the experimental group adopted the modern holistic medical model, and the full modern holistic medical model intervention was performed before, during and after the operation. The medical treatment process highlighted the overall humanistic care for the children. The age of the control group was (4.19±1.75) years old, and the age of the children in the experimental group was (4.26±1.68) years old. The operation time, the degree of surgical pain [with the pain visual analogue scale (VAS)], the postoperative complications (including postoperative hemorrhage, penile edema, infection, wound rupture), wound healing time, surgery satisfaction rate and fear level of children were compared between the two groups. Measurement data were expressed as mean±standard deviation (Mean±SD), t-test was used for comparison between groups; Chi-square test was used to compare the count data.@*Results@#In the control group, the operation time was (9.26±1.87) min, the surgical pain VAS was (2.59±0.72), postoperative bleeding was 38 (3.8%), severe penile edema was 78 (7.8%), and infection was 12 (1.2%), wound rupture was 32 cases (3.2%), the wound healing time was (20.4±2.56) d, and the surgical satisfaction rate was 67.4%. In the experimental group, the operation time of was (6.15±1.23) min, the surgical pain VAS was (1.71±0.54), postoperative bleeding was 6 cases (0.6%), severe penile edema was 12 cases (1.2%), and infection was 8 cases (0.8%), wound rupture was 2 cases (0.2%), the healing time was (15.2±3.16) d, and the operation satisfaction rate was 98.8%. The operation time, surgical pain VAS, postoperative bleeding, severe penile edema, wound splitting rate, healing time and surgical satisfaction rate were statistically significant (P<0.05), and there was no statistical difference in wound infection rate between the two groups (P>0.05). The fear level of children in the experimental group was superior to the control group at levels 0, 1, 2 and 3, the difference was statistically significant (P<0.05).@*Conclusions@#Under the intervention of modern holistic medical model, the child′s operation process is smooth, the children and parents have good subjective feelings, no obvious fear, good compliance, high satisfaction, good objective clinical effect, and positively improve the relationship between doctors and patients. The society has won a good reputation and deserves to be promoted clinically.
ABSTRACT
Objective Under the intervention of modern holistic medical model,the subjective feelings and objective effects of parents and children in circumcision were studied in children aged 3-6 years.Methods A prospective study was conducted to select 2012 children aged 3 to 6 years who underwent circumcision at the First Affiliated Hospital of Kunming Medical University from August 2013 to May 2017.The patients were divided into control group and experimental group by completely randomized grouping,there were 1 006 cases in each group.The children in the control group were treated with a single biomedical model,which was completed according to the conventional flow-type operation.The children in the experimental group adopted the modern holistic medical model,and the full modern holistic medical model intervention was performed before,during and after the operation.The medical treatment process highlighted the overall humanistic care for the children.The age of the control group was (4.19 ± 1.75) years old,and the age of the children in the experimental group was (4.26 ±1.68) years old.The operation time,the degree of surgical pain [with the pain visual analogue scale (VAS)],the postoperative complications (including postoperative hemorrhage,penile edema,infection,wound rupture),wound healing time,surgery satisfaction rate and fear level of children were compared between the two groups.Measurement data were expressed as mean ± standard deviation (Mean ± SD),t-test was used for comparison between groups;Chi-square test was used to compare the count data.Results In the control group,the operation time was (9.26 ± 1.87) min,the surgical pain VAS was (2.59 ±0.72),postoperative bleeding was 38 (3.8％),severe penile edema was 78 (7.8％),and infection was 12 (1.2％),wound rupture was 32 cases (3.2％),the wound healing time was (20.4 ± 2.56) d,and the surgical satisfaction rate was 67.4％.In the experimental group,the operation time of was (6.15 ± 1.23) min,the surgical pain VAS was (1.71 ± 0.54),postoperative bleeding was 6 cases (0.6％),severe penile edema was 12 cases (1.2％),and infection was 8 cases (0.8％),wound rupture was 2 cases (0.2％),the healing time was (15.2 ± 3.16) d,and the operation satisfaction rate was 98.8％.The operation time,surgical pain VAS,postoperative bleeding,severe penile edema,wound splitting rate,healing time and surgical satisfaction rate were statistically significant (P ＜ 0.05),and there was no statistical difference in wound infection rate between the two groups (P ＞ 0.05).The fear level of children in the experimental group was superior to the control group at levels 0,1,2 and 3,the difference was statistically significant (P ＜ 0.05).Conclusions Under the intervention of modern holistic medical model,the child's operation process is smooth,the children and parents have good subjective feelings,no obvious fear,good compliance,high satisfaction,good objective clinical effect,and positively improve the relationship between doctors and patients.The society has won a good reputation and deserves to be promoted clinically.
ABSTRACT
Drug-induced liver injury(DILI) is one of the major causes of termination of drug development.The establishment of a high-throughput test system to predict potential clinical hepatotoxicity is a valuable approach in the pharmaceutical industry.The high-content imaging-based in vitro assays allow simultaneous detection of cellular multiple parameters in the system.The real-time monitoring of multiple signaling pathways can shed light on many mechanisms of cell injury,with high sensitivity and specificity.Many types of liver cell models have been applied to high-content screening(HCS) so far.This paper introduceds the HCS technology and reviews the data of hepatotoxicity obtained from HCS technology in recent years.At the same time,we discuss the application of this technology in exploring the mechanism of hepatotoxicity and the potential of HCS technology in studying DILI and mechanisms.
ABSTRACT
Objective To compare with the efficiency between X-ray or B ultrasound guided puncture target calyces of treatment of upper urinary calculi in MPCNL.Methods From October 2010 to October 2012,we have a retrospective analysis of the 116 cases in urological department in the second affiliated hospital of Kunming Medical University,it had the sugery that was MPCNL.Selected 116 cases as the research object,(8 patients were lost to follow-up).With X-ray locating (48 cases),B ultrasound locating (53 cases),and compared with preoperative,intraoperative and postoperative clinical objective indicators of two different methods.Results X-ray locating (48 cases),the mean age was (44.86 ± 12.84) years; the mean Stone diameter(1.43 ±0.70) cm; Stone is located in the upper calyx in 1 case,the middle of calyx in 23 cases,under the calyx in 8 cases,the upper ureter in 16 cases.B ultrasonic locating (53 cases),the mean age was(46.36 ± 14.29) years; the mean Stone diameter (1.34 ±0.62) cm; Stone is located in the upper calyx in 2 cases,the middle of calyx in 24 cases,under the calyx in 8 cases,the upper ureter in 16 cases.Compared with preoperative general data of two groups,there was no statistically significant difference (P ＞ 0.05).X-ray group,the mean operation time (130.43 ± 31.63) min ; Intraoperative blood loss(80.42 ± 43.75) mL; Postoperative hospital stay (6.20 ± 2.08) d; Infected with 8 cases (17％) of postoperative,hemorrhage in 2 cases (4％) ; and calculi exhausted rate was 90％ (43/47).B Ultrasound group,the mean operation time(102.45 ± 36.32) min.Intraoperative blood loss(160.07 ± 52.33) mL;Postoperative hospital stay(5.62 ±2.37) d; Infected with 16 cases (30％) of postoperative,bleeding in 9 cases (17％) ; and calculi exhausted rate was 83％ (46/53).By comparison,X-ray and B ultrasound group in operation time,intraoperative blood loss,postoperative infection,a stone exhausted rate was statistically significant (P ＜0.05),and postoperative hospital stay,no statistical significance (P ＞ 0.05).Conclusion X-ray positioning compared with B ultrasound,X-ray is longer than B ultrasonic of operation time,but,blood much less,calculi exhausted rate is higher,and infected rate is lower.